Age-related Macular Degeneration
NEI conducts and supports research in labs and clinical centers across the country to better prevent, detect, and treat AMD.
NEI-funded research over the past decade has revealed new insight into the genetics of AMD. By screening the DNA of thousands of people with and without AMD, scientists have identified differences in genes that affect AMD risk. Armed with this knowledge, researchers are identifying key biochemical pathways involved in the disease and are exploring therapies that could interrupt these pathways. It might also be possible to develop drug therapies for AMD that are targeted specifically to a person’s unique genetic risk factors.
Scientists are also exploring ways to regenerate tissues destroyed by AMD. One approach is to make stem cells from a patient’s own skin or blood. In a lab, these stem cells can be specially treated to form sheets of retinal pigment epithelium (RPE)—the pigmented layer of tissue that supports the light-sensitive cells of the retina. The goal is to generate layers of RPE that can be implanted into the patient’s eye to preserve vision.